HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[4][5]
HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy.
Product name
Recombinant HuD Protein
Tested applications
Detection of anti-Hu paraneoplastic antibodies via Western Blot or ELISA assay.
Storage instructions Heat stable , shipped at ambient temp. Upon delivery aliquot and store in fridge , longterm storage at -20°C. Storage buffer PBS, pH 7.2 Purification notes
Expressed in E.Coli as a 6his and MBP fusion protein and purified by MBP-tag affinity chromatography
SDS gel of HuD fusion protein
10ug HuD protein
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